RO4929097

货号： 2011-1      产品名称： RO4929097   品牌： Biovision 规格： 1 mg 3周到货 生化实验

RO4929097
A potent γ-secretase inhibitor
Product Overview
Product Name: RO4929097
Alternate Name/Synonyms:
Description: RO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 847925-91-1
Molecular Formula: C₂₂H₂₀F₅N₃O₃
Molecular Weight: 469.4
Purity: ≥98% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
InChi: InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
InChi Key: OJPLJFIFUQPSJR-INIZCTEOSA-N
PubChem CID: 49867930
MDL Number: MFCD18384976
USAGE: For Research Use Only! Not For Use in Humans.

-20°C