TGX-221
货号: 10007349-100 产品名称: TGX-221 品牌: Cayman 规格: 100 碌g 3周
TGX-221
Cayman Chemical Item Number 10007349
Description Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-(3,4)-bisphosphate (PtdIns-(3,4)-P2) and PtdIns-(3,4,5)-P3).1↗,2↗,3↗ Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are 4 isoforms (p110α, p110β, p110δ, and p100γ), and a p85 regulatory subunit.3↗ TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.4↗ Inhibition appears to occur at the ATP binding site based on the observed increase in IC50 from 5 to ~50 nM at ATP concentrations of 50 µM and 1 mM, respectively. TGX-221 inhibits PtdIns-(3,4)-P2 production in platelets with an IC50 of 50 nM.4↗ Selective inhibition of PI3K p110β results in defective platelet thrombus formation and defines PI3K as a target for antithrombotic therapy.4↗
Formal Name 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
CAS Number 663619-89-4
Molecular Formula C21H24N4O2
Formula Weight 364.4
Formulation A solution in ethanol
Purity >98%
λmax 268 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES Cc1cc(C(C)Nc2ccccc2)c2nc(cc(=O)n2c1)N1CCOCC1
InCHI Code 1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3
InCHI Key CPRAGQJXBLMUEL-UHFFFAOYSA-N
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)