TGX-221

货号： 10007349-500      产品名称： TGX-221   品牌： Cayman 规格： 500 碌g 3周

TGX-221
Cayman Chemical Item Number 10007349
Description Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-(3,4)-bisphosphate (PtdIns-(3,4)-P2) and PtdIns-(3,4,5)-P3).1↗,2↗,3↗ Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are 4 isoforms (p110α, p110β, p110δ, and p100γ), and a p85 regulatory subunit.3↗ TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.4↗ Inhibition appears to occur at the ATP binding site based on the observed increase in IC50 from 5 to ~50 nM at ATP concentrations of 50 µM and 1 mM, respectively. TGX-221 inhibits PtdIns-(3,4)-P2 production in platelets with an IC50 of 50 nM.4↗ Selective inhibition of PI3K p110β results in defective platelet thrombus formation and defines PI3K as a target for antithrombotic therapy.4↗
Formal Name 7-​methyl-​2-​(4-​morpholinyl)-​9-​[1-​(phenylamino)ethyl]-​4H-​pyrido[1,​2-​a]pyrimidin-​4-​one
CAS Number 663619-89-4
Molecular Formula C21H24N4O2
Formula Weight 364.4
Formulation A solution in ethanol
Purity >98%
λmax 268 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES Cc1cc(C(C)​Nc2ccccc2)​c2nc(cc(=O)​n2c1)​N1CCOCC1
InCHI Code ​1S/C21H24N4O2/c1-15-12-18(16(2)​22-17-6-4-3-5-7-17)​21-23-19(13-20(26)​25(21)​14-15)​24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3 
InCHI Key CPRAGQJXBLMUEL-UHFFFAOYSA-N

-20°C