Prostaglandin D2-d9
货号： 10010123-50 产品名称： Prostaglandin D2-d9 品牌： Cayman 规格： 50 碌g 3周
Prostaglandin D2-d9
Cayman Chemical Item Number 10010123
Description
Prostaglandin D2-d9 (PGD2-d9) contains nine deuterium atoms at the 17, 17′, 18, 18′, 19, 19′, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGD2 by GC- or LC-mass spectrometry. PGD2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.1↗ Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes.1↗ PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.2↗,3↗ In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.2↗,3↗ Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.4↗ PGD2 inhibits human ovarian tumor cell proliferation with an IC50 value of 6.8 µM.5↗
Synonyms PGD2-d9
Formal Name 9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic-17,17,18,18,19,19,20,20,20-d9 acid
Molecular Formula C20H23D9O5
Formula Weight 361.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d9)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES O[C@@H]1[C@H](C/C=CCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C(C1)=O
InCHI Code 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1/i1D3,2D2,3D2,6D2
InCHI Key BHMBVRSPMRCCGG-UVUOTMQPSA-N
-20°C
