Gambogic amide
货号： BML-N159-0005 产品名称： Gambogic amide 品牌： Biomol 规格： 5 mg 3周到货 生化实验
A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.
Product Specification
Formula:C38H45NO7
MW:627.8
Purity:≥98% (TLC)
Appearance:Yellow-orange solid.
Solubility:Soluble in DMSO (20mg/ml) or ethanol (20mg/ml).
Long Term Storage:-20°C
-20°C
