mTOR substrate, 10 mg

货号： 12-645      产品名称： mTOR substrate, 10 mg   品牌： Millipore 规格： EA 三周到货 生化实验

mTOR Substrate
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PRODUCT FAMILY INFORMATION
Kinase & Phosphatase Products
Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
Millipore has a broad and continuously expanding portfolio of recombinant proteins. This portfolio includes more than 350 active, inactive and unactivated kinases, phosphatases and the largest available selection of disease relevant mutants. All of our enzymes are available in quantities sufficient for routine testing, as well as high throughput screening.
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Description:
mTOR Substrate
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 mg
Product Overview:
N-terminal 6His-tagged recombinant human mTOR substrate, expressed in E.coli.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene.
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UniProt Summary:
FUNCTION: SwissProt: P42345 # Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
SIZE: 2549 amino acids; 288892 Da
SUBUNIT: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.
TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in testis.
SIMILARITY: SwissProt: P42345 ## Belongs to the PI3/PI4-kinase family. & Contains 1 FAT domain. & Contains 1 FATC domain. & Contains 7 HEAT repeats. & Contains 1 PI3K/PI4K domain.
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Brand Family:
Upstate
Protein Target:
mTOR (FRAP1)
UniProt Number:
P42345
Target Sub-Family:
Lipid/Atypical
Storage Conditions:
Stable for 1 year at -80°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Packaging:
This product is also available in mg quantities. Please use 12-645-k when ordering.
Gene Symbol:
FRAP1
FRAP
RAPT1
FLJ44809
FRAP2
MTOR
mTOR
RAFT1
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Product Name:
mTOR Substrate
Entrez Gene Number:
NM_004958.2

-80℃