Anti-CD265/RANK, clone R12-31

货号： 04-1507      产品名称： Anti-CD265/RANK, clone R12-31   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-CD265/RANK, clone R12-31
Species Reactivity Key Applications Host Format Antibody Type
M  FC Rat Purified Monoclonal Antibody
Description:
Anti-CD265/RANK Antibody, clone R12-31
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Specificity:
This antibody recognizes CD265/RANK.
Molecular Weight:
~ 67 kDa
Epitope:
Unknown
Immunogen:
Mouse CD265/RANK-transfected 2PK3 cells.
Clone:
R12-31
Isotype:
IgG2aκ
Background Information:
CD265 or RANK (Receptor Activator of Nuclear Factor κ B, also known as Tumor Necrosis Factor Receptor Superfamily, member 11a or TRANCE Receptor) is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK interacts with various TRAF family proteins and induces the activation of NF-kappa B and MAPK8/JNK. RANK is also expressed on dendritic cells and facilitates immune signaling.
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Species Reactivity:
Mouse
Species Reactivity Note:
Proven to react with mouse.
Application Notes:
Flow Cytometry Analysis: 5 µg from a previous lot detected CD265/RANK in RAW264 macrophage cells.
Control:
RAW264 macrophage cells
Purification Method:
Protein G purfied
Presentation:
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
O35305
Entrez Gene Number:
NP_033425.3
Gene Symbol:
TNFRSF11A
RANK
OFE
ODFR
CD265
TRANCER
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Alternate Names:
CD265 antigen
Osteoclast differentiation factor receptor
Receptor activator of NF-KB
loss of heterozygosity, 18, chromosomal region 1
receptor activator of nuclear factor-kappa B
tumor necrosis factor receptor superfamily, member 11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
tumor necrosis factor receptor superfamily, member 11a,
activator of NFKB
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Flow Cytometry
Entrez Gene Summary:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq]
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UniProt Summary:
FUNCTION: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
SUBUNIT STRUCTURE: Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 By similarity.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.
TISSUE SPECI 2°C – 8°C