SynGAP, RBX-100UG

货号： 06-900      产品名称： SynGAP, RBX-100UG   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-SynGAP Antibody
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REFERENCES
Characterization of a novel synGAP isoform, synGAP-beta.
W Li, A Okano, Q B Tian, K Nakayama, T Furihata, H Nawa, T Suzuki, W Li, A Okano, Q B Tian, K Nakayama, T Furihata, H Nawa, T Suzuki (2001) The Journal of biological chemistry.276:21417-24
Species Reactivity Key Applications Host Format Antibody Type
R  ICC, WB Rabbit Purified Polyclonal Antibody
Description:
Anti-SynGAP Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
SynGAP
Immunogen:
peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a
Background Information:
Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.
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Species Reactivity:
Rat
Application Notes:
Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
Purification Method:
Protein A purfied
Presentation:
Purified in PBS with 0.05% NaN3 and 30% Glycerol
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
Q96PV0
Entrez Gene Number:
NM_006772.1
Gene Symbol:
SYNGAP1
RASA5
DKFZp761G1421
OTTHUMP00000064825
SYNGAP
RASA1
KIAA1938
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Key Applications:
Immunocytochemistry
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q96PV0 # Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
SIZE: 1343 amino acids; 148284 Da
SUBUNIT: Interacts CAMK2A and CAMK2B (By similarity). Interacts with MPDZ.
PTM: Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption (By similarity).
SIMILARITY: SwissProt: Q96PV0 ## Contains 1 C2 domain. & Contains 1 PH domain. & Contains 1 Ras-GAP domain.
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Brand Family:
Upstate
Product Name:
Anti-SynGAP Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
1
Target / Localization:
Postsynaptic
Format:
Purified
Host:
Rabbit
Applications:
Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.

-20°C