ANTI-HSPBAP1 Antibody (C-Terminus)

货号： 07-2048      产品名称： ANTI-HSPBAP1 Antibody (C-Terminus)   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-HSPBAP1 Antibody (07-2048), Antibody
Description:
Anti-HSPBAP1 Antibody (07-2048), Antibody
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Specificity:
This antibody detects all 3 isoforms of human HSPBAP1 in Western blots.
Molecular Weight:
~55 kDa
Epitope:
C-terminus
Immunogen:
The immunogen was a KLH-conjugated synthetic peptide corresponding to the C-terminal region of human HSPBAP1.
Background Information:
Heat Shock Protein BAP1 (heat shock 27-kDa-associated protein 1, or HSPBAP1) inhibits the function of heat shock protein 27, which has a neuroprotective effect during experimentally induced epileptic neuropathology. The HSPBAP1 protein, also known as PASS1, contains a jmjC motif, suggesting it is a member of the jumonji family of transcription factors. There is evidence of domain swapping within the jumonji family genes, and the HSPBAP1 gene has been shown to fuse with a novel gene called DIRC3 in hereditary renal cell cancer.
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Species Reactivity:
Mouse
Human
Species Reactivity Note:
Human, mouse. Not tested in other species.
Application Notes:
ELISA:
This antibody was reported by an outside laboratory to be suitable for ELISA
Immunohistochemistry:
This antibody was reported by an outside laboratory to be suitable for immunohisto-chemistry.
Immunocytochemistry:
A 1:100 dilution of anti-HSPBAP1 polyclonal antibody was used.
Western blotting:
Western blot analysis of anti-HSPBAP1 in Jurkat cell lysate. All three isoforms of HSPBAP1 are detected. The accession numbers of the isoforms are: Q96EW2; Q96EW2-2; Q96EW2-3.
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Control:
A431, HeLa, or NIH/3T3 cells
Quality Assurance:
Immunocytochemistry
Detects HSPBAP1 in the nuclei of A431, HeLa, or NIH/3T3 cells in immunofluorescent analysis.
Purification Method:
Protein G chromatography
Presentation:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
Q96EW2
Entrez Gene Number:
NP_078886.2
Gene Symbol:
FLJ22623
FLJ39386
PASS1
Alternate Names:
27 KdA heat shock protein-associated protein 1
HSPB (heat shock 27kD) associated protein 1
HSPB (heat shock 27kDa) associated protein 1
Hspb associated protein 1
Protein associated with small stress protein 1
heat shock 27 kDa associated protein
protein associating with small stress protein PASS1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry
ELISA
Immunocytochemistry
UniProt Summary:
FUNCTION: May play a role in cellular stress response By similarity.
SUBUNIT STRUCTURE: Interacts with CRYAB and HSPB1. Ref.4
SUBCELLULAR LOCATION: CytoplasmBy similarity.
TISSUE SPECIFICITY: Widely expressed. Ref.1
DISEASE: A chromosomal aberration involving HSPBAP1 is found in familial renal cell carcinoma 1 (RCC1) [MIM 2°C – 8°C