HDAC7, RBX-100UG

货号： 07-937      产品名称： HDAC7, RBX-100UG   品牌： Millipore 规格： EA 询盘 生化实验

Anti-HDAC7 Antibody (07-937)
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REFERENCES
Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation.
Gao, Chengzhuo, et al. (2008) Mol. Cell. Biol., 28: 5658-67 (2008)
Histone deacetylase inhibitors selectively suppress expression of HDAC7.
Dokmanovic, Milos, et al. (2007) Mol. Cancer Ther., 6: 2525-34 (2007)
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.
Dequiedt, Franck, et al. (2003) Immunity, 18: 687-98 (2003)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-HDAC7 Antibody
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Specificity:
This antibody recognizes human HDAC7. Does not cross-react with HDAC1, HDAC4, or HDAC8.
Molecular Weight:
100 kDa
Epitope:
a.a.164-182
Immunogen:
Synthetic peptide corresponding to amino acids 164-182 of human HDAC7 [(C)KPKKSLERRKNPLLRKESA].
Background Information:
Histone deacetylases (HDAC) are enzymes that regulates transcription by selectively deacetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of the HDAC family have been identified, divided in to two classes. Class I includes HDAC-1, 2, 3 and 8 while Class II includes HDAC-4, 5, 6, and 7. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a C-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional co-repressor complexes that can be recruited to specific promoter regions via interactions with transcription factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones, resulting in a tighter DNA-histone interaction. This compaction of chromatin leads to the repression of transcription of DNA in that region.
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Species Reactivity:
Human
Species Reactivity Note:
Reacts with Human. Not tested with other species.
Application Notes:
Western Blotting:
A previous lot of this antibody was shown to recognize recombinant HDAC7 but not recombinant HDAC1, HDAC4, or HDAC8.
Western Blotting:
A previous lot of this antibody was shown to recognize endogenous HDAC7 in HEK293T cells.
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Control:
Recombinant HDAC7 protein (Cat. #14-832).
Quality Assurance:
Routinely evaluated by Western blotting using recombinant HDAC7 protein.
Purification Method:
Affinity Purfied
Presentation:
Purified Rabbit polyclonal in buffer containing 20 mM PBS and 0.1% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8ºC from date of receipt.
UniProt Number:
Q8WUI4
Entrez Gene Number:
NP_001091886.1
Gene Symbol:
DKFZP586J0917
EC 3.5.1.98
FLJ99588
HD7
HD7A
HD7a
HDAC7A
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Alternate Names:
histone deacetylase 7
histone deacetylase 7A
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
2-8℃