ALK4, RBX-100UG

货号： 09-157      产品名称： ALK4, RBX-100UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-ALK4
Species Reactivity Key Applications Host Format Antibody Type
M, R  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-ALK4 Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes ALK4
Molecular Weight:
57 kDa
Immunogen:
Synthetic peptide designed against the N-terminal region of human ALK4
Background Information:
ALK4 (ACVR1B activin A receptor, type IB; ACVRLK4) is a transmembrane type IB receptor serine kinase for activin or activin-like ligands. Activins, are dimeric factors that belong to the TGF-superfamily of signaling proteins. Activins signal through the hetrodimeric complex that includes two type I (I and IB) and two type II (II and IIB) receptors. They type I receptors (i.e. ALK4) contains a Ser/Thr kinase domain in its cytoplasmic domain that is essential for signaling, while the type II are receptors are essential for ligand binding (Harrison, 2004 & Gray, 2000). Receptor activation involves ligand binding to the promiscuous type II receptor that is known to bind to many ligands. This leads to the recruitment of ALK4 and the formation of a stable heterodimer that results in the phosphorylation and activation of ALK4 (Harrison, 2004 & Gray, 2000).
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Species Reactivity:
Mouse
Rat
Quality Assurance:
Routinely evaluated by western blot on either mouse or rat brain lysate
Purification Method:
Affinity purified using immunogen
Presentation:
Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide with 50% glycerol.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
P36896
Entrez Gene Number:
NP_004293
Gene Symbol:
Activin receptor-like kinase 4
activin A receptor, type IB
activin A receptor, type II-like kinase 4
activin A type IB receptor
Activin receptor-like kinase 4
ACTR-IB
ACVRLK4
ALK-4
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, compo -20℃