BNP, RB X

货号： AB1549      产品名称： BNP, RB X   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Brain Natriuretic Peptide Antibody
Species Reactivity Key Applications Host Format Antibody Type
R  IHC, WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Brain Natriuretic Peptide Antibody
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Trade Name:
Chemicon (Millipore)
Specificity:
Brain Natriuretic Peptide
Molecular Weight:
13.6 kDa
Epitope:
C-Terminus
Immunogen:
Synthetic Peptide
Background Information:
Brain natriuretic peptide is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of myocytes in the ventricles. At the time of release, a co-secreted 76 amino acid N-terminal fragment (NT-proBNP) is also released with BNP. BNP binds to and activates NPRA in a similar fashion to atrial natriuretic peptide (ANP) but with 10-fold lower affinity.
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Species Reactivity:
Rat
Application Notes:
Western blot Analysis: 0.5 µg/mL detected BNP in 10 µg of Rat Spleen Lysate
Optimal working dilutions must be determined by the end user.
Control:
Tested on Rat Spleen Lysate
Purification Method:
Immunoaffinity purified
Presentation:
Purified Antibody in PBS with 0.1% NaN3
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
P16860
Entrez Gene Number:
NM_002521.2
Gene Symbol:
NPPB
BNP
OTTHUMP00000044486
Alternate Names:
BNP
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry
Western Blotting
Entrez Gene Summary:
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein’s biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
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UniProt Summary:
FUNCTION: SwissProt: P16860 # Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body’s salt and water balance. Improves heart function.
SIZE: 134 amino acids; 14726 Da
SUBUNIT: Interacts with NPR3.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Brain and also in atria, but at much lower levels than ANP.
SIMILARITY: SwissProt: P16860 ## Belongs to the natriuretic peptide family.
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Brand Family:
Chemicon
Product Name:
Anti-Brain Natriuretic Peptide Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µg
Format:
Affinity Purified
Host:
Rabbit
Applications:
This Anti-Brain Natriuretic Peptide Antibody is validated for use in IH, WB for the detection of Brain Natriuretic Pepti 2-8℃